Panola College is a member of the National Junior College Athletic Association (NJCAA), the National Intercollegiate Rodeo Association (NIRA), the Region XIV Athletic Conference, and the NIRA Southern Region. Panola College has won National Championships in Baseball in 1969, Women's Basketball in 1977 and 1978, and a Bareback National Championship in Rodeo in 2005. Since 1948 the Ponies and Fillies have won 42 conference championships, have been to the NJCAA or NIRA playoffs 95 times and the National Championship Tournaments 18 times.
The Panola Baseball team was established in 1948 and has won 29 Conference Championships, 39 trips to the NJCAA Playoffs, and qualified for the National Tournament 4 times with one National Championship.
The Fillies Volleyball team started in 1996 has won 7 conference championships, participated in 17 NJCAA playoffs, and has qualified for the National Tournament in 2009.
The Fillies Basketball program began in 1974 and won back to back National Championships in 1977 and 1978, and has won 4 Conference Championships, 18 trips to the NJCAA playoffs and has qualified for the National Tournament 5 times.
The Ponies Basketball program began in 1948 has won 2 conference championships, qualified for 14 trips to the NJCAA playoffs, and qualified for the National Tournament in 1979.
Panola's Rodeo Team was established in 2004 and has one individual National Championship in Bareback, and has qualified 7 times for the National Finals Rodeo.